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"Captivating... hard to put down."Choice
"A bracing insider's account of why gene structure matters to science and commerce."American Scientist
How genomics is bringing biology into the Digital Age
In this important book, a scientist gives us an inside account of the historic paradigm shift under way in the life sciences as a result of the Human Genome Project and provides a philosophical framework in which to understand biology and medicine as information sciences. In a story told on many fascinating levels, Gary Zweiger introduces us to the visionaries who first understood genes as information carriers and chronicles how their early efforts led to the birth of the new science of genomics. He provides insights into the uneasy collaboration of private, government, and academic efforts, the role of the pharmaceutical companies, and the influence of venture capitalists on one of the most ambitious and potentially significant scientific undertakings in history. Most important, he explores the profound impact that the transducing of biological information into a digital format already has had on biological research and medicine, and the equally profound effect it is sure to have on our understanding of ourselves and all living creatures.
- Sales Rank: #3251201 in Books
- Published on: 2002-02-01
- Original language: English
- Number of items: 1
- Dimensions: 8.90" h x .82" w x 6.00" l,
- Binding: Paperback
- 288 pages
Amazon.com Review
What has made the Human Genome Project so deeply appealing? In one sense, it's just another large-scale, big-budget effort to keep a gang of nerds busy and out of trouble for a few years. Geneticist Gary Zweiger looks askance at this and explains how the confluence of information systems, big science, and business exemplified by the HGP is actually accelerating the pace of beneficial change for all people. Transducing the Genome: Information, Anarchy, and Revolution in the Biomedical Sciences draws deeply on Zweiger's experience in biological science and biotech commerce to illuminate the scientific, economic, and legal issues relevant to the search for a more complete understanding of human genetics. Brimming with pro-capitalist optimism, he believes that the information revolution spawned the biotech explosion and will soon lead to better, cheaper solutions to a very broad range of health problems:
Knowledge of our internal information network will come mostly from an explosion of new genomic database analyses. A growing army of mathematicians and information scientists will develop increasingly powerful and more useful algorithms and computational processes for finding biomedical knowledge in these databases. A growing regiment of biologists and medical professionals with training in mathematics and information sciences will lead these knowledge discovery missions.
Zweiger assuages the reader's fears of gene patents with a brief foray into intellectual property law. It does seem unlikely that biotech patents will pose any more problems than standard pharmaceutical company practice. Combining scientific, legal, and business expertise, Transducing the Genome provides the most comprehensive overview of the birth of biotech yet written. --Rob Lightner
Review
"Gary Zweiger...provides a bracing insider's account of why gene structure matters to science and commerce. His focus is on transducing the information content of DNA into useful form. He teases out a powerful theme of genomics: its focus on methods of creating massive databases quickly." - American Scientist; "Transducing the Genome is a captivating overview of genomics. Geneticist Zweiger provides a clearly written and interesting account of the Human Genome Project, major players at the center of genome research, the origin of the genomics industry, the role of leading genomics companies, and the future prospects of the Genome Project.... This enjoyable and compelling story on genomics is har to put down." - Choice
From the Back Cover
An enthralling, behind-the-scenes look at how genomics is bringing biology into the Digital Age.
Here is our most lucid explanation yet of the significance of the Human Genome Project and the dramatic paradigm shift that it has engendered in the life sciences. In a story told on many fascinating levels, geneticist Gary Zweiger introduces us to the visionaries who first understood genes as information carriers and chronicles how their efforts led to the birth of genomics. He provides insights into the uneasy collaboration of private, government, and academic efforts; the role of the pharmaceutical companies; and the influence of venture capitalists on one of the most ambitious and significant scientific undertakings in history. Most importantly, he explores the profound impact that the transducing of biological information into digital format has had on biological research and medicine, and the equally profound effect it is certain to have on our understanding of ourselves and all living creatures.
Praise for Transducing the Genome:
"Captivating...hard to put down."
--Choice
"A bracing insider's account of why gene structure matters to science and commerce."
--American Scientist
"For a new perspective on the scientific and commercial importance of genomics from and industry viewpoint, Transducing the Genome offers nonspecialists an excellent and enjoyable introduction."
--Science magazine
"An insider's perspective on a Byzantine world involving complex, mathematically rich science, bleeding-edge technology, business decision-making in the face of uncertainty, and a thicket of legal and social concerns that could turn into big problems....a most welcome addition to the growing genomics literature."
Robert Cooke-Deegan
author of The Gene Wars: Science, Politics and the Human Genome
"Gary Zweiger has produced an outstanding history of research in Genomics. Transducing the Genome is a wonderfully readable and enjoyable book that shows us where Genomics came from, and where it is taking us."
Leonard H. Augenlicht, PhD
Professor, Medicine and Cell Biology
Albert Einstein College of Medicine, Montefiore Hospital/Oncology
Most helpful customer reviews
1 of 1 people found the following review helpful.
There are better books on this very interesting subject
By A Customer
This books has some interesting material but lacks clarity, depth and focus. Basic explanations about a given subjects come often in the wrong order. Whenever the books attempt to explain anything, very little can actually be understood, as the author tries to keep the level of explanations too low, and therefore ultimately hopelessly useless. Written with the businessman mind, and not with a scientific one.
Much better book are from Watson and Berry or from Ridley.
1 of 1 people found the following review helpful.
The role of corporate entities in the biomedical sciences.
By frumiousb
I had actually bought Transducing the Genome because I was looking for a history of genomics. While there are elements of that subject included in the book, Zweiger has really written more of a history of the field and the various players who are driving the research and change. The book looks at issues of origins, purposes, patents, the effect of computer technology on the field and finally the future potential applications.
Zweiger (employed at the time of writing by Agilent) clearly is writing from a point of view. He strongly believes that the capitalist model will take care of itself and that competition and reward will lead the way to a better future for all. He takes issue with people who oppose genome-related patents, arguing for the general benevolence of the industry and the fraternity of science. While I may (generally) agree with him, I would have preferred that he either shed the disguise of neutrality on the subject and explain his personal point of view or that he present more compelling arguments from the "other side". Most of the counter-points that he raises in the question of patenting are straw men and far too easy for him to dismiss.
While the book was very interesting, I was also a little bit lost in the structure from time to time. While the individual chapters were excellent reading, I felt that the whole did not hang together as well as it should have or could have.
This would make a particularly good book if you are interested in the biotechnology industry and the ethical issues surrounding the debate between non-profit and private sector science.
13 of 13 people found the following review helpful.
Cutting edge science, science history, business, and more
By A Customer
This is an important book. It delivers a stunning commentary on cutting edge science, technology, business, and legal developments. There is no doubt that the human genome and the technology that enabled it to be revealed will transform medicine. Zweiger explains how in a straightforward manner that is approachable to anyone. There are parts of the book that are a bit technical and other parts that breeze along. It touches on a lot of different subjects, including the role of patents, venture capital, philosphical issues, and more. I feel that the author does a good job in being unbiased. He writes from his direct experiences. He touts many companies, but he also credits the efforts of academics and is critical or a bit skeptical of many things. Most importantly, he helps the reader understand what's going on in biotechnology and genomics today, what the underlying science is and what the motivations are. It has inspired me to learn more. I highly recommend this book.
See all 8 customer reviews...
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